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Nicox offers replace on the continued analysis of naproxcinod by Fera Prescription drugs

Press launch Nicox updates on the continued evaluation of naproxcinod by Fera Prescription drugs April 30, 2021 – press launch at 7:30 a.m. CET Sophia Antipolis, France Nicox SA (Euronext Paris: FR0013018124, COX), a world ophthalmology firm, and Fera Prescription drugs, a personal firm, US Specialty Prescription drugs Firm, at present supplied an replace on Fera’s analysis of naproxcinod for future growth. Fera has examined the event alternatives of naproxcinod in quite a lot of indications and has performed preclinical growth work on naproxcinod in fashions of COVID-19 infections and sickle cell illness. Bearing in mind the information so far in COVID-19 fashions and the event atmosphere of COVID-19 therapeutics, Fera has determined to not pursue this path of analysis. Efforts will proceed to deal with sickle cell illness, the place Fera has submitted a brand new Orphan Drug Designation (ODD) software for naproxcinod in sickle cell illness, responding to considerations raised by the USA Meals and Drug Administration in its letter of request. refusal to the earlier request. , and different undisclosed therapeutic indications the place the properties of naproxcinod could also be of profit. Naproxcinod, a nitric oxide inhibitor of cyclooxygenase (NO) -donating (CINOD) naproxen, is a nonsteroidal anti-inflammatory drug candidate designed to launch NO and naproxen, initially found and developed by Nicox. Nicox and Fera entered into an settlement in December 2015, amended in September 2018 and December 2020, which granted Fera the unique rights to develop and commercialize naproxcinod for the US market. Nicox is eligible to probably obtain a one-time milestone of $ 40 million primarily based on gross sales if naproxcinod reaches $ 1 billion in annual gross sales (for any indication) in the USA in addition to a 7% royalty on internet gross sales of naproxcinod in the USA. Fera is answerable for all scientific actions. growth, manufacturing, regulatory and advertising actions in the USA Nicox retains all rights to naproxcinod exterior the USA, topic to cost of royalties to Fera, if the mental property developed beneath the The settlement is used exterior the USA About naproxcinod Naproxcinod is a nitric oxide (NO) – naproxen donation that mixes the cyclooxygenase (COX) inhibitory exercise of naproxen with that of NO (the donor NO inhibitor of COX, CINOD). Whereas the inhibitory COX element offers analgesic and anti inflammatory efficacy, the NO portion can play a major position in sustaining vascular endothelial cell perform and integrity, blood strain homeostasis, and blood strain. microvascular circulation. A big scientific suite already exists for naproxcinod in osteoarthritis, comprising three part 3 trials with greater than 2,700 sufferers. About Fera Prescription drugs Fera Prescription drugs is a privately held firm. The corporate’s purpose is to comprehend alternatives by acquisitions, licensing, growth and commercialization of New Abbreviated Drug Purposes (ANDA), New Drug Purposes (NDA) and NDA 505 (b) merchandise ( 2). Areas of curiosity embrace merchandise that would profit from lifecycle administration with a selected deal with area of interest markets. For extra data, go to About NicoxNicox SA is a world ophthalmology firm that develops modern options to assist keep imaginative and prescient and enhance eye well being. Nicox’s major scientific growth program is NCX 470, a novel nitric oxide donor prostaglandin analogue for decreasing intraocular strain in sufferers with glaucoma. The corporate can also be growing NCX 4251, a proprietary formulation of fluticasone, for acute exacerbations of blepharitis. Nicox generates income from VYZULTA® in glaucoma, licensed completely worldwide to Bausch + Lomb, and ZERVIATE® in allergic conjunctivitis, licensed in a number of geographies, together with Eyevance Prescription drugs, LLC, in the USA and Ocumension Therapeutics in China and in most nations. Southeast Asian markets. Nicox, headquartered in Sophia Antipolis, France, is listed on Euronext Paris (Compartment B: Mid Caps; Inventory image: COX) and is a part of the CAC Healthcare, CAC Pharma & Bio and Subsequent 150 indices. Info on Nicox, its merchandise or its pipeline, please go to: Analyst Protection Bryan, Garnier & Co Victor Floc’h Paris, France Cantor Fitzgerald Louise Chen New York, USEdison Funding Analysis Pooya Hemami London, UKH.C. Wainwright & Co Yi Chen New York, USKepler Cheuvreux Damien Choplain Paris, France The opinions expressed by analysts of their protection of Nicox are these of the creator and don’t mirror the views of Nicox. Moreover, the knowledge of their experiences will not be right or updated. Nicox disclaims any obligation to right or replace data contained in analyst experiences. Advisors, LLC Mary-Ann Chang T +44 7483 284 [email protected] Advisors, LLCSophie BaumontM +33 (0) 6 27 74 74 49 [email protected] Declarations The knowledge on this doc is topic to alter with out discover . This data contains forward-looking statements. These forward-looking statements will not be ensures of future efficiency. These statements are primarily based on the present expectations or beliefs of the administration of Nicox SA and are topic to quite a lot of elements and uncertainties which might trigger precise outcomes to vary materially from these described within the forward-looking statements. Nicox SA and its associates, administrators, officers, workers, advisers or brokers, don’t undertake, nor have any obligation, to offer updates or to revise forward-looking statements. Nicox’s actions are offered within the third chapter of the “ Common registration doc, annual monetary report and administration report 2020 ” filed with the Autorité des marchés financiers (AMF) on March 1, 2021, obtainable on the web site Nicox Web (www Nicox SADrakkar 2Bât D, 2405 route des DolinesCS 10313, Sophia Antipolis 06560 Valbonne, FranceT +33 (0) 4 97 24 53 00F +33 (0) 4 97 24 53 99 Attachment EN_FeraUpdate_PR_20210430_F

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